In triple-stranded DNA, the third strand binds to a B-form DNA (via Watson–Crick base-pairing) double helix by forming Hoogsteen base pairs or reversed Hoogsteen hydrogen bonds.

A well-established multi-stranded DNA structure, triple helical DNA (triplex DNA), both naturally occurring intramolecular H-DNA structures, and triplex-forming oligonucleotide (TFO)-targeted …

May 3, 2023 · The triple helix is an uncommon, unconventional and atypical DNA form that occurs only when a single strand of DNA binds with the double-stranded DNA by an unusual Hoogsteen …

Aug 24, 2025 · While the vast majority of human DNA exists as a double helix, triple helical structures do occur naturally in living systems, albeit in localized and transient forms. These structures, sometimes …

Feb 1, 2025 · Triple-helix (triplex) DNA nanostructures, distinguished by their unique triplex configuration, hold substantial promise in biomedicine, materials science, and environmental …

What is Triple-stranded DNA? Triple-stranded DNA is a DNA structure in which three oligonucleotides wind around each other and form a triple helix.

A DNA triple helix is made up of three separate DNA strands, each oriented with the sugar/phosphate backbone on the outside of the helix and the bases on the inside of the helix.

DNA is often recognized by its iconic double helix, where two strands intertwine. However, DNA can adopt alternative shapes under specific conditions, one such form being H-DNA, also known as …

May 15, 2023 · Triple-stranded DNA, also known as H-DNA, is a structure where three strands of DNA come together to form a triple helix structure. This structure is created when a single strand of DNA …

Nov 13, 2024 · Triplex DNA structures form when a third strand of DNA binds to the major groove of a DNA double helix.