Comparative efficacy of complement inhibitors in complement Inhibitor ...
Nov 3, 2025 · In this review, we aim to conduct an indirect non-head-to-head network meta-analysis of the existing randomized trials to compare the efficacy of the available agents across patient-centered …
What is the recommended treatment for patients with Paroxysmal ...
Dec 30, 2025 · Treatment Recommendations Complement Inhibitor Therapy (First-Line) For patients with PNH and clinically significant hemolysis, initiate eculizumab (or ravulizumab) as first-line therapy …
Patient Satisfaction with Use of Complement Inhibitor Injector in ...
Nov 5, 2024 · Introduction: Pegcetacoplan is a C3/C3b inhibitor approved for paroxysmal nocturnal hemoglobinuria (PNH), a rare disease characterized by complement-m…
Complement-Targeted Therapies in PNH: Where Do We Stand?
Sep 24, 2025 · “Over the past decade, significant progress has been made in the treatment of complement-dependent diseases, driven by existing unmet clinical needs and developments in drug …
Navigating the Complement Pathway to Optimize PNH Treatment …
Aug 31, 2024 · This narrative review provides an overview of the mechanisms of action of the six complement inhibitors currently approved for PNH, with a focus on the C3/C3b-targeted therapy, …
Empaveli (pegcetacoplan): Uses, Side Effects, Interactions ... - WebMD
Aug 26, 2024 · Overview: Empaveli (pegcetacoplan) helps regulate a part of your immune system called the complement system. It is used to reduce the destruction of red blood cells in people with …
Advances in Complement Inhibition Therapies for Paroxysmal …
May 28, 2025 · However, breakthrough hemolysis, infection risk, and the high cost of therapy remain persistent challenges in treating PNH (Table 1). The use of complement inhibitors in PNH is well …
New Oral Medication Reduces PNH Symptoms - Cleveland Clinic
Aug 23, 2024 · In addition to the previous contribution to pivotal trials of intravenous complement inhibitors in PNH, our center recently contributed patient data to two international phase 3 trials that …
Efficacy of complement inhibitors for patients with paroxysmal ...
Dec 14, 2023 · The development of complement inhibitors such as eculizumab, ravulizumab, and pegcetacoplan has revolutionized the management of PNH, leading to improvements in overall …
Efficacy and Safety Trials Results of Complement Inhibitors
Jun 26, 2024 · Expert panelists evaluate results regarding complement inhibitor trials for utilization in PNH management.