gut.bmj

Patient assessment of treatment satisfaction: methods and practical issues

Measurement of treatment satisfaction in gastro-oesophageal reflux disease (GORD) is compromised by an insufficient conceptual foundation and poor assessment methods. The current state of the art in ...
gut.bmj

Use and abuse of hydrogen breath tests

Correspondence to: Dr M Simrén Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, S-41345 Göteborg, Sweden; magnus.simren{at}medicine.gu.se ...
gut.bmj

Individualised therapy is more cost-effective than dose intensification in patients with Crohn’s disease who lose response to anti-TNF treatment: a randomised, controlled trial

4 Department of Hepatology and Gastroenterology V, Aarhus Hospital, Aarhus, Denmark 5 Department of Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark 6 Department of Medical Gastroenterology S, ...
Gut

Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women

Background Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut–brain axis. Objective The objective of this study was to ...
gut.bmj

A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis

Professor M W Büchler, Department of Visceral and Transplantation Surgery, University Hospital of Bern, Inselspital, CH-3010 Bern, Switzerland. BACKGROUND The pharmacological inhibition of exocrine ...
Gut

Response to ‘Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data’

We read with great interest the study by Van der Voort et al ,1 which compared rectal versus colonic submucosal cancer rates ...
GutOpinion

Red cells, red flags: are we harming stable patients with outdated transfusion thresholds?

The 2022 UK-wide acute upper gastrointestinal bleeding (AUGIB) audit by Nigam and colleagues is a landmark. With ...
gut.bmj

EUS versus MRCP to perform ERCP in patients with intermediate likelihood of choledocholithiasis: a randomised controlled trial

Objective In patients with an intermediate likelihood of choledocholithiasis, European Society of Gastrointestinal Endoscopy (ESGE) guidelines recommend endoscopic ultrasound (EUS) or magnetic ...
gut.bmj

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Correspondence to Professor Jin-Woo Bae, Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 02447, Republic of Korea; baejw{at}khu.ac.kr; ...
gut.bmj

Single-biopsy epigenetic profiling reveals persistent DNA methylation and gastric cancer risk after Helicobacter pylori eradication

Gastric cancer is a major global health concern, with ongoing efforts focused on screening and eradicating Helicobacter pylori infection.1 However, H. pylori infection is typically acquired during ...
gut.bmj

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota

Background The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn’s disease ...
gut.bmj

Pharmacological trials of early intervention in predicted severe acute pancreatitis: implications for therapeutic window and core outcome set

We read with great interest the recent randomised trial by Huang et al evaluating cyclooxygenase-2 inhibitors (COX-2-Is) in predicted severe acute pancreatitis (AP).1 Although no dose-response of ...