1Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 2Center for Human Immunobiology, Department of Medicine, Feinberg ...
Cancer Res (2025) 85 (18_Supplement_3): B004.
Abstract. TNG462 is a clinical-stage, MTA-cooperative PRMT5 inhibitor currently being evaluated in an ongoing phase I/II clinical trial for solid tumors with MTAP loss. Approximately 10-15% of all ...
Pan-RAS inhibitors have been developed for the treatment of RAS-mutant cancers. Despite the challenges in achieving clinical benefits, targeting Pan-RAS represents a novel strategy for treating these ...
Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York ...