The United States and Israel launched a major assault, as President Trump called on Iranians to overthrow the government.

The death of Ayatollah Ali Khamenei, who ruled his nation with an iron fist for nearly 37 years, raised the prospect of chaos and a power vacuum in an already turbulent region.

The strikes opened a stunning new chapter in U.S. intervention in Iran, marking the second time in eight months that the Trump administration has attacked the country during talks over its nuclear ...