BMJ

AB0067 Allosteric receptor modulation of a free fatty acid receptor turns natural agonists into potent activators of the superoxide generating neutrophil nadph-oxidase

Background Short chain fatty acids are generated in the colon by bacterial fermentation of dietary fibres and serve as natural agonists for the free fatty acid receptor 2 (FFA2R/GPR43) which belongs ...
BMJ

Type II collagen degradation and its regulation in articular cartilage in osteoarthritis

3 Faculty of Veterinary Medicine, Department of Clinical Sciences, University of Montreal, Ste-Hyacinthe, Quebec, Canada 4 Department of Orthopaedic Surgery, Jewish General Hospital, Montreal, Quebec, ...
BMJ

EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis

15 Department of Radiology. Leiden University Medical Centre, Leiden, The Netherlands 16 Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands ...
BMJ

PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome

Objectives Autoantibodies are used clinically to phenotype and subset patients with autoimmune rheumatic diseases. We detected a novel 60 kDa autoantibody specificity by immunoblotting using a ...
BMJ

Thickness of human articular cartilage in joints of the lower limb

OBJECTIVES (a) To determine the topographical variations in cartilage thickness over the entire surfaces of cadaveric lower limb joints, and (b) to examine the correlations between: cartilage ...
BMJ

Infections and the risk of incident giant cell arteritis: a population-based, case-control study

Objectives Alterations in the immune system and infections are suspected to increase susceptibility to giant cell arteritis (GCA). Recently herpes zoster has been directly implicated in the ...
BMJ

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment

Objective: To analyse the distribution of FOXP3+CD25+CD4+ regulatory T cells (Treg) in peripheral blood, synovial fluid and tissue of patients with rheumatic disease during relapse and after local ...
BMJ

The minimally important difference and patient acceptable symptom state for the Raynaud's condition score in patients with Raynaud's phenomenon in a large randomised controlled ...

1 Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA 2 MediQuest Therapeutics, Inc, Bothell, ...
BMJ

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation

1 Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK 2 Department of Rheumatology, Medical School, Newcastle University, Newcastle upon Tyne, UK 3 Department ...
BMJ

Methods of tophus assessment in clinical trials of chronic gout: a systematic literature review and pictorial reference guide

Objective To identify methods of tophus measurement for gout studies, summarise the properties of these methods and compile a detailed pictorial reference guide to demonstrate the methods. Methods A ...
BMJ

Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan H Yamada, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1 ...