Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

New findings show that the genome’s 3D structure is constantly changing, with NIPBL guiding loop formation that regulates active genes. Faulty folding dynamics may underlie cancers and developmental ...

Cells rely on biomolecular condensates to coordinate essential biological processes without surrounding membranes. These droplet-like dynamic assemblies control the way in which DNA is turned into ...

For decades, scientists viewed the genome of a newly fertilized egg as a structural "blank slate"—a disordered tangle of DNA ...

Home > Press release: A tale of coevolution: Nuclear speckles ...

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health traits. By probing regions of DNA previously linked to disease, the work has ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

Founded by Dr. Todd Lewis, the organization reflects a process-driven approach shaped by both industry experience and ...

Cells rely on biomolecular condensates to coordinate essential biological processes without surrounding membranes. These ...

Engineers at the University of Pennsylvania and Rice University have refined a technology for editing individual genetic ...

A version of this Priestley Medal address will be presented at the American Chemical Society Spring 2026 meeting ...