The agency held a meeting to gather drugmakers' perspectives as it considers a draft guidance on how previously generated ...

The world of cells is surprisingly noisy. Each cell carries unique genetic information, but when we try to measure cellular ...

Analyzing single-cell RNA sequencing (scRNA-seq) data is crucial for understanding complex biological processes and disease ...

From the moment they're born, newborns—or, specifically, their immune systems—must learn to fight germs without harming their own tissues.

One challenge of using cell therapy to treat type 1 diabetes is that this approach requires chronic suppression of the immune system to prevent rejection of donor cells. A Vertex Pharmaceuticals ...

A Vertex Pharmaceuticals cell therapy for type 1 diabetes is enabling patients to produce insulin, eliminating the need for additional insulin therapy in the vast majority of participants in a key ...

Announcement of a podium presentation at a prestigious symposium, showcasing innovative research in cell therapy for type 1 diabetes. Presentation features promising clinical data on UP421, a novel ...

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically ...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimislecel ...