New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...
Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...
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Decoding the molecular logic of histamine signaling in the brain
Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other ...
The adult midgut of the Drosophila fly: The preparation is visible under the microscope due to nuclear staining and endogenous expression of the receptor Mayo. Adhesion GPCRs belong to the large ...
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