Trent Williams in Week 18 vs. Seahawks as San Francisco fights for the NFC West title and No. 1 playoff seed at Levi's Stadium.

Trent Williams, Darnell Washington and Geno Smith were among the NFL players injured in Week 17. Injured players will be evaluated this week.

One area in which the backup-heavy 49ers struggled early in the season was the run game. McCaffrey averaged fewer than three yards per carry through the first few weeks and couldn’t break any big gains. The offense had to lean on him as a pass catcher, not as a runner.

But it’s not all good news for the 49ers. Left tackle Trent Williams was shaken up on the first play from scrimmage — Purdy’s pick-six — and is questionable to return with a hamstring injury. Austen Pleasants came in to replace him.

Trent Williams is one of the best linemen in modern NFL history, and the Sooner great suffered an injury on Sunday Night Football.

As the San Francisco 49ers push toward the final stretch of the season, veteran left tackle Trent Williams has made one thing clear: this year’s Super Bowl opportunity carries real weight. With Super Bowl LX looming, Williams believes the work being done now, especially up front, can define the team’s legacy.