Monday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Indianapolis Colts NFL Week 16 game Dec. 22, 2025.

Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 win.

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at quarterback. Here's how to watch for free.

The San Francisco 49ers, led by quarterback Brock Purdy, face the Indianapolis Colts, led by quarterback Philip Rivers, on Monday, Dec. 22, 2025 at Lucas Oil Stadium in Indianapolis, Ind.

With a mini-bye week following their loss to the Seattle Seahawks last Thursday night, the Los Angeles Rams move forward with another primetime matchup, this ti

Joe Montana was the last 49ers quarterback to throw five touchdowns when he did it in 1990.The 49ers improved to 11-4 with a fifth consecutive win. The Colts fell to 8-7, with their loss clinching playoff berths for the Bills,

Daily Fantasy multimillionaire Mike McClure reveals his daily Fantasy football picks for Indianapolis vs. San Francisco on 'MNF'

Michaels was the play-by-play voice for ABC’s “Monday Night Football” from 1986 until 2005. He was then traded to NBC when it launched “Sunday Night Football” in 2006, and he called that package until 2021. This is his fourth season doing Prime Video’s “Thursday Night Football.”