In the final game of what has been a wild Week 16, the Indianapolis Colts host the San Francisco 49ers on "Monday Night Football." The Colts come into this game starting 44-year-old Philip Rivers at quarterback after the season-ending Achilles injury to Daniel Jones.

Lack of 'quick' pressure has been a major issue for the Colts, what you need to know about the team's pass rush

The Colts are in danger of missing the postseason after a strong start to the 2025 regular season. Here are their playoff scenarios after Week 16.

After the Colts' loss to the San Francisco 49ers, Indianapolis is now 8-7 on the season. They have lost five games in a row and six of their last seven as the season continues to spiral. Using The Athletic's playoff simulator, the Colts ' playoff chances sit at just 1% -- or almost nonexistent at this point.

Having lost four games in a row and five of six, the Colts enter this week at 8-6 on the season. They are two games back of the Jaguars ' (10-4) division lead and are on the outside looking in at the AFC playoff picture, trailing the 9-5 Houston Texans for the final wildcard spot.

The Colts don't just need to beat the Jaguars to keep their minuscule playoff hopes alive. They'll need some help. A lot of it, actually.

Indianapolis Colts lose to the San Francisco 49ers and now are lost moving forward in the AFC South and AFC Conference.

Following the Indianapolis Colts' performance on Monday Night Football, here are three takeaways from what took place against the 49ers.

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the Indianapolis Colts.

Philip Rivers gave the Indianapolis Colts a chance Monday night. Their defense did not. After a 48-27 loss to San Francisco, Colts coach Shane Steichen struggled to explain why Indy could not stop the 49ers.

Young defenders ignited the 49ers' win. Winters' pick-six and Stout's coverage dominance stole the show in a statement defensive performance.